表达超抗原sEA基因的溶瘤腺病毒载体的构建与鉴定(英文)

  It is crucial that to select a proper vector for introducing thetarget gene to the target organ in the gene the

  It is crucial that to selec a proper vector for introducing thetarget gene to the target organ in the gene therapy of tumor. Manystudy mainly research the virus vectors, including the retrovirusvector, adenoviral vector, and adeno-associated virus (AAV) vec-tor, among which the adeno-associated virus vector is the mostpromising. Recently, a new virus vector, replication-selective on-colytic adenovirus (RSOAds), has attracted more attention. As akind of special virus gene therapy vector with the anti-rumor effect,it has the capabilities of selectively infecting the tumor cells andconducting large amplification and cracking the tumor cells.

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